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KMID : 0381219740060030112
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Journal of RIMSK
1974 Volume.6 No. 3 p.112 ~ p.150
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EXPERIENCES WITH ORGAN TRANSPLANTATION IN THE RAT
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Lee, Sun/이선
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Abstract
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In 1890, Heape transferred segmenting ova from fertilized rabbits to the Fallopian tubes of other female rabbits, and had pups according to Vernon and Guthrie. Four years later, Romanes reported the failure of the foreign ovary to survive within the rabbits´ or female dogs´ bodies. In 1895, Emil Knauer started an extensive investigation on ovarian implantation. The first series dealt with auto-grafting and the second series with homografting of ovaries employing rabbits. In his first experiment, he ligated the ovaries, transplanting these in part into the mesometrium or the peritoneal fold covering the horn of the uterus on the same side of the body, and in part between the fascia and muscles of the abdominal wall. Ho reported the successful nourishment of the grafted ovaries and also performed functions as well, in that Graafian follicles were developed and ova were expelled which were shown to be capable of impregnation. The normal ovarian function was extended to about a year following this procedure. Knauer found new vessels in the transplanted ovaries by the fourth post-operative day.
Woldermann Griegorieff, in 1897, autografted ovaries to the broad ligaments on 12 rabbits. He chosed the procedure in which each ovary was relocated to the broad ligament in the same side without switching them. Griegorieff reported that pregnancy resulted in 4 of the autografted series of 12. In the post-mortem examination, the ovaries were found normal with Graffian follicles visible. Jayle(1897) reported performing homografts (one rabbit to another) and heterografts (one rabbit to guinea pig) without having recorded the results. Arendt, in 1898, reported performing autografts (rabbit), homografts (rabbits) and heterografts (rabbit to cat) of the ovaries in substantial numbers, and found atrophied grafts. The grafting technique was identical to that of Griegorieff choosing the broad ligament as the recipient site and hoping that the transplanted ovaries would grow in a new locality but they atrophied. Within 6 to 12 weeks, the uterus and cornu were atrophied as the new ovarian grafts atrophied.
Hugo Ribbert, in 1898, autografted guinea pigs´ ovaries into the broad ligament and found that the primordial follicles were still vital and even showed proliferations 30 days after the
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